Foreword
Introduction
1 Scope
2 Normative references
3 Terms and definitions
4 Symbols and abbreviated terms
4.1 Symbols
4.2 Abbreviated terms
5 Performance Measures
5.1 Decision threshold (y[*]) and Detection Limit (y[#])
5.1.1 Preamble
5.1.2 General procedure for the determination of the
characteristic limits
5.2 Relative bias and bias performance criteria
5.3 Repeatability performance criteria
6 Performance criteria for in vivo radiobioassay
6.1 General
6.2 Service laboratory criteria
6.2.1 General
6.2.2 Equipment
6.2.3 Services
6.2.4 Location
6.3 Identification of radionuclides
6.4 Quantification
6.5 Reporting results
6.6 Records retention
7 Performance criteria for in vitro radiobioassay
7.1 General
7.2 Responsibilities of the customer that could impact
the service laboratory's performance
7.3 Analytical methodology
7.3.1 General
7.3.2 Analytical equipment and facilities
7.3.3 Operating procedures and instructions
7.4 Reporting results
7.5 Records retention
8 Quality assurance and quality control for radiobioassay
laboratories
8.1 General
8.2 Quality assurance
8.3 Quality assurance plan
8.3.1 Points of the plan
8.3.2 Responsible quality assurance person or organization
8.4 Quality control
8.4.1 General
8.4.2 Quality control procedures
8.4.3 Performance checks of instrumentation for in vivo and
in vitro radiobioassay
8.4.4 Performance checks on in vitro (biological samples)
radiobioassay procedures
8.4.5 Performance criteria checks for in vivo and in vitro
radiobioassay
8.4.6 Use of reference radioactive materials for equipment
calibrations
9 Performance testing programme
9.1 General
9.2 In vivo radiobioassay
9.2.1 General
9.2.2 Testing protocols
9.2.3 Test categories
9.2.4 Test radionuclides and activity ranges
9.2.5 Test phantom for lung measurement
9.2.6 Test phantom for total body measurements
9.2.7 Test phantoms for thyroid and for other types of
in vivo measurement
9.3 In vitro radiobioassay
9.3.1 General
9.3.2 Testing protocol
9.3.3 Test radionuclides and activity ranges
Annex A (informative) Detection Limit - Models for applications
A.1 Model in ionizing-radiation measurements
A.2 Model for general chemical analytics
A.3 General expressions of practical use
Annex B (informative) Detection Limit - Application examples
B.1 Example 1: Direct measurement of an internal
contamination with WBC (linear background)
B.1.1 The model
B.1.2 The associations
B.1.3 Standard uncertainty
B.1.4 Decision threshold y[*]
B.1.5 Detection Limit y[#]
B.2 Example 2: Determination of plutonium by alpha
spectrometry
B.2.1 The model
B.2.2 The associations
B.2.3 Standard uncertainty
B.2.4 Decision threshold y[*]
B.2.5 Detection Limit y[#]
B.3 Example 3: Determination of uranium in urine by ICP-MS
B.3.1 The model
B.3.2 The associations
B.3.3 Standard uncertainty
B.3.4 Decision threshold y[*]
B.3.5 Detection Limit y[#]
B.4 Example 4: Tritium measurement in urine samples with LSC
B.4.1 The model
B.4.2 The associations
B.4.3 Standard uncertainty
B.4.4 Decision threshold y[*]
B.4.5 Detection Limit y[#]
Bibliography