PD ISO/TR 13014:2012

Foreword
Introduction
1 Scope
2 Terms and definitions
3 Symbols and abbreviated terms
4 Importance of physico-chemical properties to
  toxicological assessment
5 Parameters for the physico-chemical characterization
  of manufactured nano-objects prior to
  toxicological assessment
6 Expression of measurement results and uncertainties
7 Reporting
Annex A (informative) - Diagram illustrating the use of
        physico-chemical characterization in
        toxicological testing
Annex B (informative) - Example measurement methods
        and standards
Bibliography

Gives guidance for the physico-chemical characterization of manufactured nano-objects and their aggregates and agglomerates (NOAA) greater than 100 nm presented for toxicological testing in order to aid in assessing and interpreting the toxicological impact of manufactured nano-objects and to allow the material under test to be differentiated from seemingly similar materials.

This Technical Report provides guidance for the physico-chemical characterization of manufactured nano- objects and their aggregates and agglomerates (NOAA) greater than 100nm presented for toxicological testing in order to aid in assessing and interpreting the toxicological impact of manufactured nano-objects and to allow the material under test to be differentiated from seemingly similar materials. For each of the selected properties, a description, clarification, relevance, measurand and example measurement methods are provided.

This Technical Report will be of value to parties (e.g. toxicologists, ecotoxicologists, regulators, health and safety professionals) interested in assessing and interpreting the potential toxicological effect of manufactured NOAAs.