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  • ISO 29701:2010

    Current The latest, up-to-date edition.

    Nanotechnologies Endotoxin test on nanomaterial samples for in vitro systems Limulus amebocyte lysate (LAL) test

    Available format(s):  Hardcopy, PDF, PDF 3 Users, PDF 5 Users, PDF 9 Users

    Language(s):  English, French

    Published date:  03-09-2010

    Publisher:  International Organization for Standardization

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    Abstract - (Show below) - (Hide below)

    ISO 29701:2010 describes the application of a test using Limulus amebocyte lysate (LAL) reagent for the evaluation of nanomaterials intended for cell-based in vitro biological test systems. The test is suitable for use with nanomaterial samples dispersed in aqueous media, e.g. water, serum or reaction medium, and to such media incubated with nanomaterials for an appropriate duration at 37 C.

    ISO 29701:2010 is restricted to test samples for in vitro systems, but the methods can also be adapted to nanomaterials to be administered to animals by parenteral routes.

    General Product Information - (Show below) - (Hide below)

    Development Note Supersedes ISO/DIS 29701. (09/2010)
    Document Type Standard
    Publisher International Organization for Standardization
    Status Current

    Standards Referenced By This Book - (Show below) - (Hide below)

    S.R. CWA 17253-2:2018 JOINT IMPLANTS - PART 2: TIERED TOOLKIT APPROACH TO EVALUATE THE BIOLOGICAL IMPACT OF WEAR PARTICLES FROM JOINT REPLACEMENTS AND RELATED DEVICES
    16/30284330 DC : 0 BS ISO 19007 - NANOTECHNOLOGIES - IN VITRO MTS ASSAY FOR MEASURING THE CYTOTOXIC EFFECT OF NANOPARTICLES
    ISO/TR 10993-22:2017 Biological evaluation of medical devices — Part 22: Guidance on nanomaterials
    ISO/TR 19601:2017 Nanotechnologies — Aerosol generation for air exposure studies of nano-objects and their aggregates and agglomerates (NOAA)
    PD ISO/TR 19601:2017 Nanotechnologies. Aerosol generation for air exposure studies of nano-objects and their aggregates and agglomerates (NOAA)
    ISO/TR 16196:2016 Nanotechnologies Compilation and description of sample preparation and dosing methods for engineered and manufactured nanomaterials
    PD ISO/TS 19337:2016 Nanotechnologies. Characteristics of working suspensions of nano-objects for in vitro assays to evaluate inherent nano-object toxi city
    PD ISO/TS 19006:2016 Nanotechnologies. 5-(and 6)-Chloromethyl-2’,7’ Dichlorodihydrofluorescein diacetate (CM-H2DCF- DA) assay for evaluating nanoparticle-induced intracellular reactive oxygen species (ROS) production in RAW 264.7 macrophage cell line
    ISO/TS 19337:2016 Nanotechnologies — Characteristics of working suspensions of nano-objects for in vitro assays to evaluate inherent nano-object toxicity
    ISO/TS 19006:2016 Nanotechnologies — 5-(and 6)-Chloromethyl-2’,7’ Dichloro-dihydrofluorescein diacetate (CM-H2DCF-DA) assay for evaluating nanoparticle-induced intracellular reactive oxygen species (ROS) production in RAW 264.7 macrophage cell line
    PD ISO/TR 10993-22:2017 Biological evaluation of medical devices Guidance on nanomaterials

    Standards Referencing This Book - (Show below) - (Hide below)

    ISO 14644-2:2015 Cleanrooms and associated controlled environments Part 2: Monitoring to provide evidence of cleanroom performance related to air cleanliness by particle concentration
    ISO 10993-12:2012 Biological evaluation of medical devices Part 12: Sample preparation and reference materials
    ISO 14644-7:2004 Cleanrooms and associated controlled environments — Part 7: Separative devices (clean air hoods, gloveboxes, isolators and mini-environments)
    ISO 14644-1:2015 Cleanrooms and associated controlled environments Part 1: Classification of air cleanliness by particle concentration
    ISO/TS 80004-1:2015 Nanotechnologies — Vocabulary — Part 1: Core terms
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