Abstract
Committee Membership
Foreword
1 Scope
2 Introduction
3 Definitions
4 Specifications
4.1 Organization of Water Purity Specifications
4.2 Clinical Laboratory Reagent Water (CLRW)
4.3 Special Reagent Water (SRW)
4.4 Instrument Feed Water
4.5 Water Supplied by a Method Manufacturer for Use as a
Diluent or Reagent
4.6 Prepackaged Bottled Water
4.7 Autoclave and Wash Water Applications
5 Validation and Trend Monitoring
5.1 Validation of Purified Water as Fit for Its Intended
Purpose in Laboratory Procedures
5.2 Trend Monitoring of Water Purity Specifications
5.3 Water Purification System Validation
6 Design Considerations
6.1 Filters
6.2 Reverse Osmosis (RO) Membranes
6.3 Contactor Membranes
6.4 Ion-Exchange Resins
6.5 Activated Carbon
6.6 Distillation
6.7 Ultraviolet Light
6.8 Storage and Distribution
7 Testing
7.1 Resistivity
7.2 Microbial Content by Colony Count
7.3 Microbial Content by Epifluorescence Microscopy
7.4 Endotoxins
7.5 Determination of Oxidizable Organic Substances,
Expressed as Total Organic Carbon (TOC)
References
Additional References
Appendix A. Permeability of Plastic Piping to Atmospheric
CO[2]
Appendix B. Resistivity Measurement in a Sparged Water
Sample
Appendix C. Methods for Correction or Compensation of
Resistivity Measurements
Summary of Comments and Subcommittee Responses
The Quality System Approach
Related CLSI/NCCLS Publications