Pressure regulators integrated with cylinder valves intended for the administration of medical gases in the treatment, management, diagnostic evaluation and care of patients for use with the following medical gases: oxygen, nitrous oxide, air for breathing, helium, carbon dioxide, xenon, specified mixtures of the gases listed above, air for driving surgical tools, nitrogen for driving surgical tools. Pressure regulators are intended to be fitted to high pressure cylinders with filling pressure up to 20 000 kPa and can be provided with devices which control and measure the flow of the medical gas delivered to the patient.