EN 16418:2014
Current
The latest, up-to-date edition.
Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)
02-04-2014
This European Standard specifies a test method for the laboratory assessment of the potential cytotoxic effect of paper and board intended to come into contact with foodstuffs using specifically the HepG2 cell line.Compared to the EN 15845[1], HepG2 cells are more representative of a human oral exposure to xenobiotics, due to the presence in the cells of phase I, II and III enzymes of the metabolism.
| Committee |
CEN/TC 172
|
| DevelopmentNote |
Supersedes PREN 16418. (04/2014)
|
| DocumentType |
Standard
|
| PublisherName |
Comite Europeen de Normalisation
|
| Status |
Current
|
| Supersedes |
| Standards | Relationship |
| DIN EN 16418 E : 2014 | Identical |
| NEN EN 16418 : 2014 | Identical |
| NS EN 16418 : 2014 | Identical |
| DIN EN 16418:2014-07 | Identical |
| UNI EN 16418 : 2014 | Identical |
| UNE-EN 16418:2014 | Identical |
| NF EN 16418 : 2014 | Identical |
| PN EN 16418 : 2014 | Identical |
| SN EN 16418 : 2014 | Identical |
| I.S. EN 16418:2014 | Identical |
| BS EN 16418:2014 | Identical |
| NBN EN 16418 : 2014 | Identical |
| EN 645:1993 | Paper and board intended to come into contact with foodstuffs - Preparation of a cold water extract |
| EN 15845:2010 | Paper and board - Determination of the cytotoxicity of aqueous extracts |
| ISO 3696:1987 | Water for analytical laboratory use — Specification and test methods |
| EN ISO 3696:1995 | Water for analytical laboratory use - Specification and test methods (ISO 3696:1987) |
| EN 647:1993 | Paper and board intended to come into contact with foodstuffs - Preparation of a hot water extract |
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