PD CR 13903:2001

CONTENTS
Foreword
Introduction
1. General
   1.1 Background
   1.2 Physiology
   1.3 Intended medical use
   1.4 Concentration/dose of inhaled nitric oxide in medical use
   1.5 Pharmacokinetics
   1.6 Side effects of inhaled nitric oxide
   1.7 References
2. Chemical and physical properties
   2.1 Chemical properties
   2.2 Physical properties
   2.3 Toxicity (personal)
   2.4 Occupational safety limits
   2.5 References
3. Compatibility of materials with nitric oxide
   3.1 General
   3.2 List of examples of materials
   3.3 The use of soda lime to absorb nitric oxide and
       nitrogen
   3.4 Literature
4. Supply systems
   4.1 Design criteria for supply system for nitric
       oxide/nitrogen mixtures
   4.2 Characteristics of the components of the supply systems
   4.3 Pipeline systems
   4.4 Use of anaesthetic gas scavenging systems
   4.5 Supply systems for emergency and transport
   4.6 References
5. Delivery systems for nitric oxide/nitrogen mixtures
   5.1 Sudden withdrawal of nitric oxide in dependency situations
   5.2 Examples of nitric oxide delivery systems
   5.3 Monitoring
   5.4 Effects of nitric oxide on the ventilator
   5.5 Further reading
6. Transportation of neonates

This standard gives information on the properties and medical uses of nitric oxide and guidance on medical equipment through which this gas passes before and after administration to the patient. This report is primarily intended for these involved in the standardization and manufacture of such medical equipment and for those concerned with the practice of inhaled nitric oxide therapy.