EN ISO 19238:2017

European foreword
Foreword
Introduction
1 Scope
2 Terms and definitions
3 Dicentric assay
4 Responsibility of the customer
5 Responsibility of the service laboratory
6 Confidentiality of personal information.
7 Laboratory safety requirements
8 Calibration curve(s)
9 Scoring unstable chromosome aberrations
10 Criteria for converting a measured
   aberration frequency into an estimate of
   absorbed dose
11 Reporting of results
12 Quality assurance and quality control
Annex A (informative) - Sample instructions for customer
Annex B (informative) - Sample questionnaire
Annex C (informative) - Sample of report
Annex D (informative) - Fitting of the low-LET
        dose-response curve by the method of maximum
        likelihood and calculating the error of dose estimate
Annex E (informative) - Odds ratio method for cases
        of suspected exposure to a low dose
Annex F (informative) - Sample data sheet for
        recording aberrations
Bibliography

ISO 19238:2014 provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by cytogenetic service laboratories.ISO 19238:2014 addressesa) the confidentiality of personal information, for the customer and the service laboratory,b) the laboratory safety requirements,c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from chromosome aberration frequency and the minimum resolvable doses,d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry,e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose,f) the reporting of results,g) the quality assurance and quality control,h) informative annexes containing sample instructions for customer, sample questionnaire, sample of report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of dose estimate, odds ratio method for cases of suspected exposure to a low dose, and sample data sheet for recording aberrations.